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Prior work has shown that the distribution of birth weight is linked to social disadvantage. To determine whether the association between birth weight and adult weight gain differs by social disadvantage, we used repeated measurements of weight and weight gain among 2,388 men and women who were part of the Coronary Artery Risk Development in Young Adults (CARDIA) Study. During a follow-up period of 9 to 11 years, when subjects were aged 26 to 30, weight gain averaged 2.6 pounds for men and 2.8 pounds for women. An increase in birth weight of 250 g was associated with an increased weight gain in both men and women of 2 pounds (95% confidence interval [CI]: 1.8 to 2.1) and 2.3 pounds (95% CI: 2.2 to 2.5), respectively. Differences in the association between birth weight and adult weight gain by social disadvantage were evident. The odds ratio associated with birth weight increased by 0.11 (95% CI: 0.05 to 0.25) for men and 0.18 (95% CI: 0.08 to 0.37) for women with each increase of 250 g. For men, the association was greater for those with lower social disadvantage, whereas for women, the association was greater for those with the highest levels of social disadvantage. These findings suggest that the association between birth weight and adult weight gain differs by social disadvantage.Maximizing Preexcitation for Structural and Functional Studies of Cardiac Ion Channels.
Ion channels are fascinating protein complexes that allow for selective ion permeation across biological membranes. These protein complexes have been described to form the molecular basis of a wide variety of physiological phenomena, such as electrical excitation and contraction, salt and water homeostasis, and cell volume regulation. Although many breakthroughs have been made in elucidating the function of these complexes, the overall picture is still elusive. This is largely because of the challenging task of functional studies, which requires the integration of electrophysiological 0b46394aab
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