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Current research on the link between magnesium (Mg) and cardiovascular diseases is inconclusive. To date, only one study examined Mg supplementation in postmenopausal women with ischemic cardiovascular disease (IHD). The present study was conducted to evaluate the effectiveness and safety of Mg supplementation in such women. A double-blind, placebo-controlled study was conducted for 24 months, in which 98 women with IHD were randomly assigned to either Mg or placebo group (n = 49 per group) in a 1:1 ratio. Mg (300 mg/d) or placebo was supplied by a commercial supplement company. The primary endpoint was progression of IHD, defined as a 15% drop in exercise capacity or ICD implantation. Among 98 participants who completed the study, Mg supplementation reduced the progression of IHD (p = 0.021) and all-cause mortality (p = 0.021). Compared with placebo, Mg supplementation reduced all-cause mortality (p = 0.018) in the intention-to-treat (ITT) analysis, although it 0b46394aab